![]() 1, C and D) were detected in the nasal turbinate, soft palate, and tonsils of all four ferrets inoculated with these two viruses but were not detected in any other organs tested. The nasal turbinate, soft palate, tonsils, trachea, lung, heart, liver, spleen, kidneys, pancreas, small intestine, and brain from each ferret were collected for viral RNA quantification by quantitative polymerase chain reaction and virus titration in Vero E6 cells. Pairs of ferrets were inoculated intranasally with 10 5 plaque-forming units (PFU) of F13-E or CTan-H and euthanized on day 4 postinoculation (p.i.). Two virus strains were used in this study: (i) SARS-CoV-2/F13/environment/2020/Wuhan (F13-E), isolated from an environmental sample collected in the Huanan Seafood Market in Wuhan, and (ii) SARS-CoV-2/CTan/human/2020/Wuhan (CTan-H), isolated from a human patient. ![]() We therefore tested the susceptibility of ferrets to SARS-CoV-2. Ferrets are commonly used as an animal model for viral respiratory infections in humans ( 20– 26).
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